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. 2021 Aug 11;12:698249. doi: 10.3389/fimmu.2021.698249

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Copyright © 2021 Feng, Min, Liang, Chen, Chen, Zhou, Deng, Liu and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restricting NETs reduces tissue damage and promotes motor function recovery after SCI. (A) Representative images of H&E staining performed on the injured spinal cord section of each group at 28 days after operation. Scale bars = 2 mm. (B) Representative recording of motor evoked potentials (MEPs) of each group at 28 days after operation. Scale: 5 mV/10 ms. (C) Amplitudes of MEPs of each group. Data are presented as means ± SD of n = 6 (*p < 0.05 versus vehicle). (D) The BBB scores at different time points of each group. Data are presented as means ± SD of n = 6 (*p < 0.05 sham versus DMSO, ^$ p < 0.05 sham versus Saline, p < 0.05 CI-amidine versus DMSO, ^& p < 0.05 DNase1 versus Saline).