Fig. 2.

Symptoms and complications across time periods for all adult patients with SMA (n = 446). GI = gastrointestinal; SMA = spinal muscular atrophy. Other respiratory illness, symptom, or insufficiency includes acute and chronic bronchitis, acute and chronic sinusitis, acute tonsillitis, acute upper respiratory infection, respiratory infection, respiratory symptom or insufficiency, and cold/cough/fever/influenza. Ventilation support is defined by codes listed in Supplemental Table 1 and includes intermittent positive pressure breathing device, respiratory treatments (cough assist/suction machine), bilevel positive airway pressure (BiPAP)/continuous positive airway pressure (CPAP), and tracheostomy. GI-related issues include esophagitis/reflux, dysphagia, feeding problems, gastrostomy (G-tube) feeding/upper GI procedures. Musculoskeletal problems include muscle weakness, lack of coordination, osteoporosis/fracture/other bony abnormality, scoliosis, contracture/dislocation/subluxation. Support/therapy includes occupational therapy and wheelchairs. Surgery includes scoliosis surgery and other surgeries.