Table 1. Characteristics of BNT162b2-Vaccinated Health Care Workers with Breakthrough Infections.^*.

Characteristic	Patient 1	Patient 2	Patient 3	Patient 4
Sex	Female	Female	Female	Female
Age (yr)	35	28	40	48
Coexisting conditions	None	None	None	None
Profession	Nurse	Medical student	Midwife	Technician
Vaccine	BNT162b2	BNT162b2	BNT162b2	BNT162b2
Time from first to second vaccine dose (days)	21	21	21	21
Vaccine-related reactions	Local pain	None	Local pain	Local pain
Reason for PCR testing	Symptoms or illness in unvaccinated household contact	Routine staff screening	Symptoms or illness in unvaccinated household contact	Symptoms or illness in unvaccinated household contact
Time from second vaccine dose to infection (days)	52	47	71	72
Symptoms of infection†	Day 1, sore throat and dyspnea	Day 1, none; day 2, rhinorrhea and cough	Day 1, none; day 5, rhinorrhea and loss of sense of smell and taste	Day 1, none; day 3, rhinorrhea and myalgia
Ct values for N1/N2†	Day 1, 34/35	Day 1, 20/20; day 4, 20/24; day 17, 39/39	Day 1, 19/19; day 14, 33/32	Day 1, 25/25; day 14, 30/30; day 20, 36/33; day 24, 34/32
Day of first negative PCR result†	Day 5	Day 22	Day 18	Day 32
Variant of concern	B.1.1.7 (household contact)‡	B.1.1.7	B.1.1.7	B.1.1.7
Clinically relevant mutations in gene encoding spike	Not determined	delHV69/70, N501Y, A570D, D614G, and P681H	delHV69/70, N501Y, A570D, D614G, and P681H	delHV69/70, N501Y, A570D, D614G, and P681H

^*Ct denotes cycle threshold, N1 nucleocapsid 1, N2 nucleocapsid 2, and PCR polymerase chain reaction.

^†Timing is relative to the time of diagnosis (diagnosis occurred on day 1).

^‡Material was not available for PCR testing in this patient; identification of the variant of concern is based on test results for the household contact.