Figure 3.

Glomerular hemodynamic function and size selectivity of the glomerular capillary in Pima Indians with type 2 diabetes. A: Changes in mean glomerular filtration rate from baseline to the end of follow-up in subjects with impaired glucose tolerance, newly diagnosed type 2 diabetes, and diabetes of long duration and normoalbuminuria, microalbuminuria, and macroalbuminuria. Each arrow connects the value at the baseline examination and the value at the end of follow-up. The dashed line indicates the time of diabetes diagnosis and the shaded area the 25th–75th percentiles of values in subjects with normal glucose tolerance. Adapted with permission from Nelson et al. (17). B: Comparison of the fractional dextran clearance profiles in the group with diabetes and the normal glucose tolerance group. The horizontal bars represent 1 SE for each sieving coefficient. The subjects with newly diagnosed diabetes show a significant elevation of the sieving curve at its large radius end. *P < 0.05 in the groups with diabetes vs. normal glucose tolerance. Adapted with permission from Myers et al. (16). C: Comparison of the fractional dextran clearance profiles in subjects with diabetes of long duration and macroalbuminuria (MACRO) (red) or normoalbuminuria (blue). The error bars represent 1 SD for each sieving coefficient. The subjects with macroalbuminuria show a significant elevation of the sieving curve at its large radius end and a tendency toward depression at the low-radius end. *P < 0.05 in macroalbuminuria vs. normoalbuminuria groups. Adapted with permission from Lemley et al. (15) D: Kaplan-Meier estimates of ESKD-free survival according to latent class hemodynamic parameter trajectories. Those with unstable trajectories who are at high risk of progression to ESKD and those in the low-risk group with stable trajectories are shown. P_GLO, intraglomerular pressure; R_A/R_E, ratio of afferent to efferent arteriolar resistance.