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. 2021 Aug 13;70(8):1603–1616. doi: 10.2337/dbi20-0043

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© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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JAK/STAT canonical pathway in human DKD as assessed by Ingenuity Pathway Analysis software. The JAK/STAT family members represented include JAK1, JAK2, and JAK3 and STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. The mRNA expression changes for JAK/STAT family members in early (Pima Indians, n = 22–24) (left panel) and progressive (Caucasian, n = 7–11) (right panel) human DKD are indicated in red for increased expression and green for decreased expression, compared with the corresponding control group (living donors (LD) and minimal change disease (MCD), n = 7–12). Adapted with permission from Berthier et al. (83). Prog., progressive.