Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 13;70(8):1603–1616. doi: 10.2337/dbi20-0043

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

PMC Copyright notice

Schematic representation of the study design to identify structural parameters in the tubulointerstitium (TubInterstitium) that coexpress with long-term clinical outcomes. In step 1, modules or groups of genes with similar expression profiles are constructed from the transcriptome profile using a weighted gene coexpression analysis (WGCNA) strategy. In step 2, a module eigengene (ME) is derived from each module and associated with clinical and structural parameters (ACR, albumin-to-creatinine ratio; iGFR, iothalamate glomerular filtration rate; VvInt, cortical interstitial fractional volume). The heat map table illustrates the correlation coefficients of the ME and the tested parameters. The significant modules (marked by *) are then further investigated for functional enrichments (GO, gene ontology). Reprinted with permission from Nair et al. (85).