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. 2021 Aug 13;70(8):1603–1616. doi: 10.2337/dbi20-0043

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© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Transcriptional network analysis showing significant pathways (P ≤ 0.05) enriched by VvInt correlated transcripts (VvInt, cortical interstitial fractional volume). Pathways are connected by one or more shared genes. The network displays two principal domains driven by negatively correlated (left) transcripts enriched for metabolic processes and positively correlated (right) transcripts enriched for inflammatory processes. The nodes (pathways) are connected by genes (edges) shared among them. Ingenuity Pathway Analysis (Ingenuity Systems, QIAGEN, Redwood City, CA). Reprinted with permission from Nair et al. (85) TCA, tricaroxylic acid.