Table 4.
Serum carnitine, acylcarnitines, and acylcarnitine ratios of groups
Control subjects | T2D patients with hyperglycemia | KPD patients with DKA | T1D patients with DKA | |
---|---|---|---|---|
N | 17 | 21 | 52 | 21 |
Carnitine (µmol/L) | 27.0 ± 1.9 | 25.0 ± 2.4 | 14.9 ± 1.7ab | 15.1 ± 1.8ab |
Acylcarnitine from fatty acids (µmol/L) | ||||
C16 | 0.072 ± 0.005 | 0.075 ± 0.009 | 0.129 ± 0.009ab | 0.148 ± 0.018ab |
C14 | 0.020 ± 0.003 | 0.019 ± 0.003 | 0.038 ± 0.005ab | 0.055 ± 0.011ab |
C8 | 0.134 ± 0.019 | 0.147 ± 0.031 | 0.228 ± 0.032 | 0.236 ± 0.040 |
C2 | 6.4 ± 0.46 | 13.4 ± 2.7 | 27.2 ± 2.7ab | 26.8 ± 2.3ab |
Acylcarnitine ratios | ||||
C16-to-C14 ratio | 3.9 ± 0.19 | 4.4 ± 0.32 | 3.5 ± 0.32 | 4.3 ± 0.26 |
C16-to-C8 ratio | 0.67 ± 0.08 | 0.89 ± 0.16 | 0.84 ± 0.11 | 1.01 ± 0.11 |
C16-to-C2 ratio | 0.012 ± 0.001 | 0.007 ± 0.001a | 0.006 ± 0.001a | 0.006 ± 0.001a |
C14-to-C8 ratio | 0.182 ± 0.031 | 0.199 ± 0.028 | 0.254 ± 0.033 | 0.266 ± 0.047 |
C14-to-C2 ratio | 0.003 ± 0.00 | 0.002 ± 0.000a | 0.002 ± 0.000a | 0.002 ± 0.000a |
C8-to-C2 ratio | 0.022 ± 0.004 | 0.011 ± 0.001a | 0.009 ± 0.001a | 0.009 ± 0.001a |
Data are means ± SEM. Because data were not normally distributed, nonparametric one-way ANOVA (Kruskal-Wallis test) was performed with post hoc Dunn multiple comparisons.
Value significantly different from that of control subjects (P < 0.05).
Value significantly different from that of T2D group (P < 0.05).