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. 2021 May 25;70(8):1885–1897. doi: 10.2337/db21-0070

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© 2021 by the American Diabetes Association

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Scatter plot of RTqPCR data depicting expression levels for GLIS3, a monogenic diabetes gene in the category β-cell development (Supplementary Table 7). The FD is calculated based on the ratio of the means (Research Design and Methods). See Research Design and Methods for statistical analysis (P values and q values [estimation of false discovery rates]). N/D refers to number (N) of samples yielding no data out of the total (D). B: Widefield IF of GLIS3 (green) and overlay with insulin (INS), glucagon (GCG), and somatostatin (SST) from a control and T1D pancreas. Yellow outlines depict the islets to illustrate the significant reduction of GLIS3 in the T1D islet. Final panel in each row shows combined GLIS3 ISH (RNAscope [green dots]) coupled with IF for CD99 and KRT19. Magnification bars = 40 μm.