Table 2.
ISR genes
| Gene | T1D (n = 25–30) | AAB+ (n = 20–24) | ||||
|---|---|---|---|---|---|---|
| FD | P value | q value | FD | P value | q value | |
| ALS2 | 12.36 | <0.001 | <0.001 | 0.60 | 0.703 | 0.179 |
| ATF4 | 1.27 | 0.306 | 0.097 | ND | ||
| ATF6 | 2.78 | 0.004 | 0.004 | 0.85 | 0.869 | 0.216 |
| BLOC1S1 | 1.48 | 0.379 | 0.115 | ND | ||
| COL6A2 | 8.25 | <0.001 | <0.001 | 0.50 | 0.598 | 0.163 |
| DDIT3/CHOP | 1.83 | 0.073 | 0.037 | ND | ||
| DNAJB11 | 4.58 | <0.001 | <0.001 | 4.35 | <0.001 | <0.001 |
| DNAJB9 | 5.61 | <0.001 | <0.001 | 0.45 | 0.905 | 0.223 |
| DNAJC3 | 1.81 | 0.225 | 0.078 | ND | ||
| EDEM1 | 18.11 | <0.001 | <0.001 | 1.20 | 0.113 | 0.050 |
| EIF2AK1 | 2.12 | 0.142 | 0.058 | ND | ||
| EIF2AK2 | 2.90 | 0.015 | 0.010 | 0.20 | 0.043 | 0.024 |
| EIF2AK3 | 8.32 | <0.001 | <0.001 | 3.41 | <0.001 | <0.001 |
| EIF2AK4 | 4.47 | 0.002 | 0.002 | 0.79 | 0.170 | 0.065 |
| EIF2S1 | 2.14 | 0.082 | 0.039 | ND | ||
| ERN1/IRE1a | 5.86 | 0.012 | 0.009 | 0.28 | 0.002 | 0.002 |
| FEN1 | 8.37 | <0.001 | <0.001 | 2.47 | 0.001 | 0.001 |
| HSP90B1 | 4.07 | 0.002 | 0.002 | 0.56 | 0.358 | 0.111 |
| HSPA5 | 2.54 | 0.122 | 0.051 | ND | ||
| MBTPS1 | 3.12 | 0.026 | 0.015 | 0.08 | 0.017 | 0.011 |
| MBTPS2 | 2.77 | 0.159 | 0.063 | 0.14 | <0.001 | 0.001 |
| MSMO1 | 2.40 | 0.045 | 0.025 | 0.40 | 0.291 | 0.093 |
| MVK | 6.43 | <0.001 | <0.001 | 0.97 | 0.204 | 0.076 |
| NELFA | 7.48 | <0.001 | <0.001 | 1.65 | 0.017 | 0.011 |
| PDIA4 | 8.38 | <0.001 | <0.001 | 1.26 | 0.075 | 0.037 |
| PPP1R15A | 9.48 | <0.001 | <0.001 | 0.47 | 0.689 | 0.176 |
| TMBIM6 | 4.42 | <0.001 | <0.001 | 0.76 | 0.689 | 0.176 |
| VCP | 12.44 | <0.001 | <0.001 | 1.05 | 0.078 | 0.038 |
| XBP1s | 3.81 | 0.138 | 0.057 | ND | ||
| XBP1u | 1.48 | 0.361 | 0.111 | ND | ||
Tabulated FDs, P values, and q values for the ISR genes showing altered expression in T1D and autoantibody+ (AAB+) pancreata. n refers to the number of independent pancreata in each cohort, and boldface type denotes genes showing altered expression. Of 30 ISR genes tested, 20 showed differential expression in T1D pancreata. Of the 20 genes altered in T1D, 8 showed differential expression in the autoantibody+ cohort (4 genes were induced and 4 repressed). ND, not done.