Table 1.
Clinical and pathologic characteristics of all consecutive patients who underwent curative-intent resection (n = 487)
| Variable | All n = 487 | RCC n = 182 | LCC n = 305 | P-value† | HAI n = 275 | Non-HAI n = 212 | P-valuea |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Age | 58.8 (25.3–90.7) | 62.5 (27.2–90.7) | 56.5 (25.3–87.0) | < 0.01 | 55.5 (25.3–84.2) | 64.6 (25.7–90.7) | < 0.01 |
| Gender | |||||||
| Male | 265 (54) | 98 (54) | 167 (55) | 0.85 | 148 (54) | 117 (55) | 0.76 |
| Female | 222 (46) | 84 (46) | 138 (45) | 127 (46) | 95 (45) | ||
| Laterality | |||||||
| Right | 182 (37) | N/A | N/A | N/A | 83 (30) | 99 (47) | < 0.01 |
| Left | 305 (63) | 192 (70) | 113 (53) | ||||
| Adjuvant HAI | |||||||
| Yes | 275 (56) | 83 (46) | 192 (63) | < 0.01 | N/A | N/A | N/A |
| No | 212 (44) | 99 (54) | 113 (37) | ||||
| RAS status | |||||||
| Wild-type | 299 (61) | 85 (47) | 214 (70) | < 0.01 | 178 (65) | 121 (57) | 0.09 |
| Mutant | 188 (39) | 97 (53) | 91 (30) | 97 (35) | 91 (43) | ||
| Number of metastases | 2 (1–15) | 2 (1–10) | 2 (1–15) | 0.09 | 3 (1–15) | 2 (1–12) | < 0.01 |
| Solitary metastasis | |||||||
| Yes | 158 (32) | 60 (33) | 98 (32) | 0.85 | 62 (23) | 96 (45) | < 0.01 |
| No | 329 (68) | 122 (67) | 207 (68) | 213 (77) | 116 (55) | ||
| 3+ CLM | |||||||
| Yes | 169 (35) | 54 (30) | 115 (38) | 0.07 | 123 (45) | 46 (22) | < 0.01 |
| No | 318 (65) | 128 (70) | 190 (62) | 152 (55) | 166 (78) | ||
| Synchronous | 310 (64) | 115 (63) | 195 (64) | 0.87 | 185 (67) | 125 (59) | 0.06 |
| Metachronous | 177 (36) | 67 (37) | 110 (36) | 90 (33) | 87 (41) | ||
| DFI < 12 months | 389 (80) | 149 (82) | 240 (79) | 0.34 | 228 (83) | 161 (76) | 0.06 |
| Size of largest lesion (cm) | 2.9 (0.2–20.0) | 2.8 (0.6–20.0) | 3.0 (0.2–20.0) | 0.42 | 2.5 (0.2–20.0) | 3.0 (0.6–15.6) | 0.04 |
| Nodal status of primary tumor | |||||||
| Node positive | 317 (65) | 121 (66) | 196 (64) | 0.62 | 178 (65) | 139 (66) | 0.85 |
| Node negative | 170 (35) | 61 (34) | 109 (36) | 97 (35) | 73 (34) | ||
| Margin Status | |||||||
| Positive | 44 (9) | 13 (7) | 31 (10) | 0.26 | 24 (9) | 20 (9) | 0.79 |
| Negative | 443 (91) | 169 (93) | 274 (90) | 251 (91) | 192 (91) | ||
| CRS 3–5 | 248 (53) | 94 (54) | 154 (52) | 0.68 | 154 (62) | 94 (38) | 0.03 |
| Lesions ablated | |||||||
| Yes | 105 (22) | 39 (21) | 66 (22) | 0.96 | 78 (28) | 27 (13) | < 0.01 |
| No | 382 (78) | 143 (79) | 239 (78) | 197 (72) | 185 (87) | ||
| Extra-hepatic disease | 35 (7) | 18 (10) | 17 (6) | 0.07 | 15 (5) | 20 (9) | 0.09 |
| 2-stage hepatectomy | 40 (8) | 14 (8) | 26 (9) | 0.75 | 35 (13) | 5 (2) | < 0.01 |
Abbreviations: RCC = right colon cancer; LCC = left colon cancer; HAI = hepatic artery infusion; CLM = colorectal liver metastases; DFI = disease-free interval; CRS = clinical risk score
a
P-value from chi-square test for categorical variables or Wilcoxon rank sum test for numeric variables