Table 2:

Multivariate Analysis of Predictors of recurrence-free survival (n = 480)

Variable	Hazard Ratio	95% Hazard Ratio CI	P-value
HAI therapy	0.68	0.53 – 0.87	< 0.01
Age	0.10	0.99 – 1.01	0.89
Number of lesions	1.13	1.07 –1.20	< 0.01
Size of largest lesion	1.08	1.04 – 1.13	< 0.01
Laterality (left)	1.13	0.89 – 1.44	0.32
Lesions ablated	1.36	1.03 – 1.79	0.03
Sex (male)	1.12	0.89 – 1.40	0.35
RAS (mutant)	1.49	1.17 – 1.88	< 0.01
Extra-hepatic disease	2.01	1.33 – 3.03	< 0.01
2-stage hepatectomy	1.39	0.93 – 2.08	0.11
DFI < 12 months	1.74	1.26 – 2.42	< 0.01
Node positive tumor	1.58	1.23 – 2.03	< 0.01
Positive margins	1.79	1.23 – 2.60	< 0.01

Abbreviations: HAI = hepatic artery infusion; DFI = disease-free interval