Table 3.

Multivariate Analysis of Predictors of Overall Survival after Curative-Intent Resection of CLM (n = 487)

Variable	Hazard Ratio	95% Hazard Ratio CI	P-value
HAI therapy	0.52	0.39 – 0.70	< 0.01
Age	1.01	1.00 – 1.03	0.03
Number of lesions	1.13	1.05 – 1.22	< 0.01
Size of largest lesion	1.04	1.00 – 1.09	0.08
Laterality (left)	0.83	0.63 – 1.11	0.21
Lesions ablated	1.29	0.92 – 1.81	0.15
Sex (male)	1.26	0.95 – 1.67	0.11
RAS (mutant)	1.60	1.20 – 2.13	< 0.01
Extra-hepatic disease	2.56	1.62 – 4.06	< 0.01
2-stage hepatectomy	1.90	1.21 – 2.97	< 0.01
DFI < 12 months	1.25	0.86 – 1.81	0.24
Node positive tumor	1.80	1.32 – 2.44	< 0.01
Positive margins	2.55	1.70 – 3.81	< 0.01

Abbreviations: HAI = hepatic artery infusion; DFI = disease-free interval