Table 2.

Genomic factors related to radiation responsiveness

Proliferation	Ploidy/S-phase studies
Genomic	Chromosomal abnormalities e.g., chromosomal loss or amplification, copy number variation (CNV), or translocations
Mutations	Tumor burden, specific targeted mutations e.g., TP53 or ATM, or gene-fusions
GWAS	Single nucleotide polymorphisms (SNPs)
Transcription	Transcriptomics e.g., whole exome, mRNA, miRNA, lncRNA
Epigenome	Chromosomal modifications (transcriptome-targeting, or structural) e.g., methylation, acetylation

GWAS = genome wide association studies, lncRNA = long non-coding RNA, mRNA = messenger RNA, miRNA = microRNA