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. 2021 Aug 11;13:709215. doi: 10.3389/fnagi.2021.709215

Table 2.

Comparison of SEN, SPEC, PPV, NPV, and AUC with 95% CI among the DLB vs. ND, DLB vs. AD, and DLB vs. non-DLB groups using a cutoff score of 3/2 for the HAI-MDQ, a cutoff score of 1.37/1.38 for the SBR, and a cutoff score of 6/5 for the combination of the MDQVR or MDQSBR.

SEN SPEC PPV NPV AUC (95% CI)
HAI-MDQ
   DLB vs. ND 0.91 0.68 0.85 0.80 0.87 (0.84–0.94)
   DLB vs. AD 0.91 0.76 0.85 0.86 0.89 (0.84–0.94)
   DLB vs. Non-DLB 0.91 0.72 0.73 0.91 0.89 (0.85–0.93)
SBR
   DLB vs. ND 0.91 0.89 0.97 0.84 0.93 (0.89–0.97)
   DLB vs. AD 0.91 0.72 0.83 0.85 0.93 (0.89–0.97)
   DLB vs. Non-DLB 0.91 0.80 0.79 0.92 0.90 (0.86–0.94)
MDQVR
   DLB vs. ND 0.87 0.97 0.98 0.79 0.98 (0.96–1.00)
   DLB vs. AD 0.87 0.91 0.93 0.82 0.95 (0.93–0.98)
   DLB vs. Non-DLB 0.87 0.93 0.92 0.89 0.96 (0.94–0.98)
MDQSBR
   DLB vs. ND 0.86 0.97 0.98 0.78 0.98 (0.96–1.00)
   DLB vs. AD 0.86 0.90 0.92 0.81 0.95 (0.92–0.98)
   DLB vs. Non-DLB 0.86 0.93 0.91 0.89 0.96 (0.94–0.98)

SEN, sensitivity; SPEC, specificity; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; DLB, Lewy body dementia; ND, non-dementia control; AD, Alzheimer's disease; SBR, striatal–background ratio of dopamine transporter imaging; HAI-MDQ, motor dysfunction questionnaire in the History-based Artificial Intelligence Clinical Dementia Diagnostic System; MDQVR, the composite scale of MDQ and DAT VR scale; MDQSBR, the composite scale of MDQ and SBR.