Table 2.
Comparison of SEN, SPEC, PPV, NPV, and AUC with 95% CI among the DLB vs. ND, DLB vs. AD, and DLB vs. non-DLB groups using a cutoff score of 3/2 for the HAI-MDQ, a cutoff score of 1.37/1.38 for the SBR, and a cutoff score of 6/5 for the combination of the MDQVR or MDQSBR.
SEN | SPEC | PPV | NPV | AUC (95% CI) | |
---|---|---|---|---|---|
HAI-MDQ | |||||
DLB vs. ND | 0.91 | 0.68 | 0.85 | 0.80 | 0.87 (0.84–0.94) |
DLB vs. AD | 0.91 | 0.76 | 0.85 | 0.86 | 0.89 (0.84–0.94) |
DLB vs. Non-DLB | 0.91 | 0.72 | 0.73 | 0.91 | 0.89 (0.85–0.93) |
SBR | |||||
DLB vs. ND | 0.91 | 0.89 | 0.97 | 0.84 | 0.93 (0.89–0.97) |
DLB vs. AD | 0.91 | 0.72 | 0.83 | 0.85 | 0.93 (0.89–0.97) |
DLB vs. Non-DLB | 0.91 | 0.80 | 0.79 | 0.92 | 0.90 (0.86–0.94) |
MDQVR | |||||
DLB vs. ND | 0.87 | 0.97 | 0.98 | 0.79 | 0.98 (0.96–1.00) |
DLB vs. AD | 0.87 | 0.91 | 0.93 | 0.82 | 0.95 (0.93–0.98) |
DLB vs. Non-DLB | 0.87 | 0.93 | 0.92 | 0.89 | 0.96 (0.94–0.98) |
MDQSBR | |||||
DLB vs. ND | 0.86 | 0.97 | 0.98 | 0.78 | 0.98 (0.96–1.00) |
DLB vs. AD | 0.86 | 0.90 | 0.92 | 0.81 | 0.95 (0.92–0.98) |
DLB vs. Non-DLB | 0.86 | 0.93 | 0.91 | 0.89 | 0.96 (0.94–0.98) |
SEN, sensitivity; SPEC, specificity; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; DLB, Lewy body dementia; ND, non-dementia control; AD, Alzheimer's disease; SBR, striatal–background ratio of dopamine transporter imaging; HAI-MDQ, motor dysfunction questionnaire in the History-based Artificial Intelligence Clinical Dementia Diagnostic System; MDQVR, the composite scale of MDQ and DAT VR scale; MDQSBR, the composite scale of MDQ and SBR.