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. 2021 Aug 25;6:315. doi: 10.1038/s41392-021-00740-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a 3E8 suppressed the infection of Vero E6 cells by live SARS-CoV-2. b Application of 3E8 significantly reduced the viral RNA loads in the lungs of BALB/c mice ectopically expressing human ACE2 and inoculated with live SARS-CoV-2 virus. RBD-targeting monoclonal antibody B38 and isotype were used as positive and negative controls, respectively. c H&E staining of lung organ samples from different treatment groups. PBS- and isotype-treated mice developed serious interstitial pneumonia characterized with large area of alveolar septal thickening, large number of inflammatory cell infiltration (black arrow), even formed vascular cuff around blood vessels (yellow arrow), bleeding areas (blue arrow), and material exudates from the alveolar cavity (green arrow). B38-treated mice showed slightly-less histological pneumonia than the two groups. Only inflammatory cell infiltration (black arrow) and formed vascular cuff around blood vessels (yellow arrow) were observed in the lungs of 3E8-treated mice. The scale represents 100 μm. *p < 0.05; **p < 0.01