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. 2021 Aug 11;11:725549. doi: 10.3389/fonc.2021.725549

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Copyright © 2021 Placke, Rawitzer, Reis, Rashidi-Alavijeh, Livingstone, Ugurel, Hadaschik, Griewank, Schmid, Schadendorf, Roesch and Zimmer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conventional H&E staining suggests significant differences in frequency of apoptosis between CPI-associated gastritis and common types of gastritis. (A) Histological H&E image of CPI-associated gastritis shows numerous suspected apoptotic events in the glandular epithelia. (B) IFGM without suspected apoptotic events, (C) Type-A and (D) type-B gastritis with isolated suspected apoptotic events in the glandular epithelia. (E) Type-C gastritis with no suspected apoptosis in the glandular epithelia. H&E staining at 200× magnification. →, apoptosis; CPI, checkpoint inhibition; H&E, hematoxylin&eosin staining; IFGM, Inflammation free gastric mucosa.