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. 2021 Aug 11;11:725549. doi: 10.3389/fonc.2021.725549

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Copyright © 2021 Placke, Rawitzer, Reis, Rashidi-Alavijeh, Livingstone, Ugurel, Hadaschik, Griewank, Schmid, Schadendorf, Roesch and Zimmer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case 1: gastroscopy and histologic findings. (A) Gastroscopy before initiation of corticosteroids with signs of erosive pangastritis. (B) Biopsy before corticosteroids with severe inflammation of the antral mucosa, lymphocyte infiltrates, eosinophilic and neutrophilic granulocytes, and numerous apoptotic events (H&E, 200× magnification). (C) Gastroscopy 4 weeks after corticosteroids showing marked improvement of inflammation and discrete prepyloric antrum gastritis. (D) Specimen biopsy 4 weeks after corticosteroids showing low lymphoplasmacytic cell infiltrate in the stroma and only isolated eosinophilic granulocytes (H&E, 200× magnification). H&E, hematoxylin&eosin staining; , apoptosis; , eosinophilic granulocytes; , neutrophilic granuolocytes; , lymphocytes.

Inline graphic — Case 1: gastroscopy and histologic findings. (A) Gastroscopy before initiation of corticosteroids with signs of erosive pangastritis. (B) Biopsy before corticosteroids with severe inflammation of the antral mucosa, lymphocyte infiltrates, eosinophilic and neutrophilic granulocytes, and numerous apoptotic events (H&E, 200× magnification). (C) Gastroscopy 4 weeks after corticosteroids showing marked improvement of inflammation and discrete prepyloric antrum gastritis. (D) Specimen biopsy 4 weeks after corticosteroids showing low lymphoplasmacytic cell infiltrate in the stroma and only isolated eosinophilic granulocytes (H&E, 200× magnification). H&E, hematoxylin&eosin staining; , apoptosis; , eosinophilic granulocytes; , neutrophilic granuolocytes; , lymphocytes.