Table 1.

Characteristics of melanoma patients with CPI-associated gastritis.

Patient	1	2	3	4	5
Stage (AJCC, eighth edition)	IV	IV	IV	IV	IV
Age	41	38	45	54	52
Sex	Female	Male	Male	Female	Female
Other autoimmune events	Hepatitis (concurrent with gastritis)	Lichen ruber (4 months before gastritis)	Hypophysitis Thyroiditis (2 months before gastritis)	Thyroiditis (3 months before gastritis)	None
Weight loss	None	9 kg in 3 w	10 kg in 3 w	8 kg in 3 w	None
Clinical symptoms	Nausea	Nausea	Heartburn	Nausea
	Vomiting	Vomiting	Appetite loss	Vomiting	Hemoglobin loss
		Epigastric pain	Nausea
Time between start of CPI and occurrence of symptoms (days)	29	336	118	166	50
Last therapy before onset of gastritis	Ipilimumab and nivolumab	Pembrolizumab and epacadostat	Nivolumab	Nivolumab and relatlimab	Ipilimumab and nivolumab
Previous therapies	None	None	Ipilimumab/nivolumab	None	BRAF/MEK inhibition

AJCC, American Joint Committee on Cancer; CPI, checkpoint inhibition; w, weeks.