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. 2021 Aug 11;12:705973. doi: 10.3389/fgene.2021.705973

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Copyright © 2021 Jin, Zeng, Guo, Dong, Tang and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Pedigree of the WS family with three patients. The black symbols represent the affected members, and the arrow indicates the proband. (B–E) Partial phenotypes of three patients. Proband (II:3) had bilateral finger contractures with mild cutaneous syndactyly (B), dystopia canthorum, and faint synophrys (C); her father (I:1) had dystopia canthorum, bright blue eyes, and prominent nasal root (D); her brother (II:2) had dystopia canthorum, bilateral bright blue eyes, synophrys, white forelock, and prominent nasal root (E).