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. 2021 Aug 11;12:719009. doi: 10.3389/fimmu.2021.719009

Figure 4.

Figure 4

Hypoxia induced a pro-inflammatory response without activation of NF-κB in high active sarcoidosis. (A–D) Concentrations of CXCL8 (A), TNFα (B), IL-1ß (C) and IL-10 (D) assessed by Luminex® in conditioned media of normoxic and hypoxic MD-macrophages from controls, high active sarcoidosis (AS), and low active or inactive sarcoidosis (IS); results are expressed in pg/ml (n= 5-8 controls or patients/group). (E, F) NF-κB-p65 and p50 activation (measured as OD450nm) assessed by TransAM ®. Each point indicates a patient and/or control (n= 7-8/group). Results are expressed as box plot showing 25th and 75th percentile and median. *p < 0.05; **p < 0.01; ***p < 0.001 in two-way ANOVA-repeated measures with Sidak post-hoc test.