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. 2021 Aug 11;12:719009. doi: 10.3389/fimmu.2021.719009

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Copyright © 2021 Jeny, Bernaudin, Valeyre, Kambouchner, Pretolani, Nunes, Planès and Besnard

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxia promoted a profibrotic response in high active sarcoidosis. (A) Active (free) and total (free+latent) TGß1 (in pg/ml) measured by ELISA in conditioned media from MD-macrophages after 24hrs of normoxia. (n= 7-14 independent experiments). (B–D) Concentrations of total TGFß1 (B), PDGF-BB (C) and PAI-1 (D) assessed by Luminex^® in conditioned media of normoxic and hypoxic MD-macrophages from controls, high active sarcoidosis (AS), and low active or inactive sarcoidosis (IS). Each point indicates a patient and/or control (n= 5-8/group). Results are expressed in pg/ml with box plot showing 25^th and 75^th percentile and median. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 in two-way ANOVA-repeated measures and two-way ANOVA with Sidak post-hoc test.