Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of bisphosphonates on nsp9 modification. (A) Cryo-EM structure of the SARS-CoV-2 RdRp with PPi bound to the NiRAN domain AS2. PDB: 7AAP (39). (B) Inhibition of NMPylation by PPi and bisphosphonates; structures are shown below each compound. (C) Bisphosphonates do not promote the removal of NMP from modified nsp9. In (B) and (C), signal intensity was compared to that observed in the absence of added ligands (set at 1) and is shown as mean ± SD (n = 3).
