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. 2021 Aug 25;22:247. doi: 10.1186/s13059-021-02460-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cross validation of generated datasets defining the chromatin landscape of FLS. a Log fold change enrichment of chromatin states as defined by ChromHMM in open chromatin regions as identified by ATAC-seq. b Log fold change enrichment of chromatin states as defined by ChromHMM in prey fragments of Capture HiC measurements. c Log fold change enrichment of chromatin states as defined by ChomHMM in consistent TAD boundaries. d Basal average expression of genes (RNA-seq counts) across non-TSS, TSS, and random ChromHMM annotations. TSS = transcription start site, TSS_F = flanking TSS; TSS_up = upstream TSS; TSS_down = downstream TSS; Tx = Transcription; Enh_gene = enhancer genic; ZNF = zinc finger; Het_chrom = heterochromatin