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. 2021 Aug 24;19:169. doi: 10.1186/s12915-021-01101-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2. — “Incompatible” fused cells (via CATs) often escape incompatibility-triggered cell death. a Examples of the four observed types of cellular behavior following CAT-mediated fusion of “compatible” and “incompatible” cells. Strains shown: Ls.17 H1-mCherry paired with Cf.38 H1-sGFP (I), Ls.17 H1-sGFP (II), PH H1-sGFP (III), and BB H1-sGFP (IV). Arrows: nuclei undergoing degradation; arrowheads: migrating nuclei; asterisks: cell shrinkage. Bars = 5 μm. b Frequencies of the four types of cellular behavior in self, “compatible”, and “incompatible” pairings. The numbers of detected events in each case are provided in brackets (detailed results in Additional file 2: Table S2). c Frequency of nuclear migration through CATs in viable heterokaryons resulting from self, “compatible”, and “incompatible” pairings. Bars = SD. In b, c, statistical significance of differences between the compared groups was tested with one-way ANOVA followed by Tukey’s post hoc test; in b, groups marked by the same superscript character did not differ significantly; in c, ** p value ≤ 0.01; ns: non-significant (p value > 0.05)