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. 2021 Aug 11;12:650816. doi: 10.3389/fphar.2021.650816

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Copyright © 2021 Lu, Chen, Zhang, Tang, Zhang, Ma, Tang, Li, Wu, Wei, Li, Yang, Han and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FZHFZY exerts a protective effect against imiquimod (IMQ)-induced psoriasis. (A) Photographs of the backs of mice on day 9 after the first FZHFZY application. All mice were randomly divided into five groups, and dexamethasone (DEX) or FZHFZY administration began 2 days before daily IMQ cream application for 7 days. (B) Severity of psoriasis during the course of IMQ-induced psoriasis, was evaluated by the scores on the psoriasis area and severity index (PASI). (C) Haematoxylin and eosin (H&E) staining of skin tissue from different groups of mice (magnification×200, scale bar = 50 μm). (D) Epidermal thickness of mouse dorsal skin (***p < 0.001 vs. IMQ-induced psoriasis group; n = 6).