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. 2021 Aug 11;12:713265. doi: 10.3389/fmicb.2021.713265

Figure 1.

Figure 1

Performance of BG assay for Pneumocystis pneumonia diagnosis in HIV-negative population. (A) Serum BG levels (pg/ml) in patients with Pneumocystis pneumonia and in colonized patients. Black horizontal bars, median values. The median value for PCP patients was 2,771 pg/ml (range, 31–5,000; interquartile range, 3,490 pg/ml). The median value for colonized patients was 31 pg/ml (range, 31–119; interquartile range, 23 pg/ml). Serum BG levels were significantly lower in the colonization group than in the PCP group (Mann–Whitney test, p < 0.001). (B) Receiver operating characteristic curve for serum BG assay performance, using microscopic detection of Pneumocystis jirovecii as the reference method. Red arrows represent calculated thresholds for maximal specificity (156 pg/ml) and maximal sensitivity (38 pg/ml). AUC, area under the curve; BG, (1,3)-β-D-glucan; and PCP, Pneumocystis pneumonia.