Table 3.
Biodistribution of 177Lu-octreotate in IMR-32-bearing nude mice. Data is given as 177Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue 177Lu activity concentration ratios (T/N) at 1, 24 and 168 h after injection of 15 MBq 177Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)
| 177Lu activity concentration (%IA/g) | |||
|---|---|---|---|
| 15 MBq | |||
| Time p.i. | 1 h | 24 h | 168 h |
| Adrenals | 3.2 (0.3) | 1.1 (0.2) | 0.61 (0.14) |
| Blood | 2.3 (0.3) | 0.039 (0.006) | 0.0087 (0.0013) |
| Brain | 0.22 (0.02) | 0.046 (0.003) | 0.017 (0.001) |
| Kidneys | 43 (3) | 18 (1) | 1.4 (0.1) |
| Liver | 2.9 (0.4) | 0.34 (0.04) | 0.18 (0.03) |
| Lungs | 6.3 (1.1) | 1.3 (0.1) | 0.39 (0.03) |
| Spleen | 3.6 (0.4) | 0.30 (0.02) | 0.19 (0.04) |
| Tumor | 17 (2) | 11 (1) | 11 (3) |
| Tumor-to-normal-tissue concentration ratio (T/N) | |||
| T/N | 1 h | 24 h | 168 h |
| Adrenals | 6.1 (0.9) | 14 (3) | 22 (6) |
| Blood | 8.8 (1.1) | 330 (46) | 1300 (290) |
| Brain | 86 (12) | 330 (84) | 740 (190) |
| Kidneys | 0.38 (0.04) | 0.80 (0.16) | 7.8 (1.9) |
| Liver | 6.9 (0.9) | 41 (7) | 70 (22) |
| Lungs | 3.0 (0.3) | 11 (2) | 29 (8) |
| Spleen | 5.4 (0.6) | 50 (12) | 100 (47) |