Unique case identifiers with AJCC stage (where available) and TNM classification for random forest algorithm development and testing. Cases CRC10-14 and NIW1-3 from the Monte Carlo algorithm development were also included in the training set, and CRC18 and NIW4 were used in blinded testing (see Table 1). AJCC = American Joint Commission on Cancer⁵².

Case ID	Case notes	AJCC stage	TNM classification
Training set
CRC1	Moderately differentiated adenocarcinoma in caecum	I	T2N0Mx
CRC2	Moderately differentiated adenocarcinoma in ascending colon	IIA	T3N0Mx
CRC3	Well differentiated adenocarcinoma in ascending colon	IIIB	T3N1Mx
CRC4	Moderately differentiated adenocarcinoma in ascending colon	I	T1NxMx
CRC5	Moderately differentiated adenocarcinoma in caecum	X	T3N0Mx
CRC6	Poorly differentiated adenocarcinoma in descending colon	X	T4N1Mx
CRC7	Poorly differentiated adenocarcinoma in rectum	X	T3N0Mx
CRC8	Poorly differentiated mucinous carcinoma in transverse colon	X	T1N0Mx
CRC9	Poorly differentiated mucinous carcinoma in caecum	X	T3N0Mx
CRC10	Moderately differentiated adenocarcinoma in ascending colon	X	T3bN0M0
CRC12	Moderately differentiated adenocarcinoma in sigmoid colon	X	T4N1M0
Blinded testing set
CRC14	Well differentiated adenocarcinoma in ascending colon	IIA	T3N0Mx
CRC15	Moderately differentiated adenocarcinoma in descending colon	IIA	T3N0Mx
CRC16	Moderately differentiated adenocarcinoma site unknown	U	T2N0Mx
CRC17	Moderately differentiated adenocarcinoma in sigmoid colon	IIIB	T3N1Mx
CRC19	Poorly differentiated adenocarcinoma in sigmoid colon	X	T3N1Mx