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. 2021 Aug 11;12:723038. doi: 10.3389/fphar.2021.723038

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Copyright © 2021 Kulikov, Shipaeva, Dmitrieva, Batrak, Shipunov, Guy, Smith, Zhang, Zhang, Duan, Chestukhin, Barbashov, Samsonov and Lavrovsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPR analysis of the RPH-120 binding to human, cynomolgus or mouse PD-L1. RPH-120 was immobilized on a CM5 sensor chip then human, monkey or mouse Fc-tagged PD-L1 (Panel A) or His-tagged PD-L1 (Panel B) proteins were applied at 30 µl/min for 1 min to generate the sensograms.