Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic model of the interplay between triggering receptor expressed on myeloid cells 2 (TREM2) and Toll-like receptor 4 (TLR4)-induced inflammation after subarachnoid hemorrhage (SAH). The TLR4-induced inflammation suppresses the TREM2 signaling pathway to exacerbate SAH-triggered inflammatory response in microglia. After SAH onset, the activated TLR4 pathway can interfere TREM2 by inhibiting the increment of TREM2 expression and cleaving TREM2 into a secreted form.
