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. 2021 Aug 11;9:693342. doi: 10.3389/fcell.2021.693342

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Copyright © 2021 Hu, Li, Wang, Chen, Qian and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Triggering receptor expressed on myeloid cells 2 (TREM2) mediates the microglial survival and phagocytic capacity at 12 h following subarachnoid hemorrhage (SAH). (A,B) Immunofluorescence labeling and quantitative apoptotic percentage of the microglia were revealed in vitro. (C,D) Double immunofluorescence staining of TREM2 and CD68 was detected and quantified. (E) The phagocytic capacity was evaluated using Escherichia coli conjugated to pHrodo. These data are shown as mean ± SEM (*p<0.05, **p<0.01, ***p<0.001, ****p<0.001; A, scale bar = 50 μm; C, scale bar = 25 μm).