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. 2021 Aug 11;9:693342. doi: 10.3389/fcell.2021.693342

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Copyright © 2021 Hu, Li, Wang, Chen, Qian and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toll-like receptor 4 (TLR4) pathway is involved in regulating the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in vitro after subarachnoid hemorrhage (SAH). (A–D) Infusion with GI254023X or MyD88 inhibitory peptide (MIP) fusion protein was used to detect the regulatory effect of TLR4 on TREM2. (E–I) The protein levels of MyD88, P38, ADAM10, TREM2, and β-actin were quantified by Western blotting. (J) ELISA detection showed the changes of soluble TREM2. (K,L) The microglial viability and phagocytic capacity were measured to assess microglial activity associated with TREM2. These data are shown as mean ± SEM (^nsp>0.05, *p<0.05, **p <0.01, ***p<0.001, ****p<0.001).