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. 2021 Aug 11;9:693342. doi: 10.3389/fcell.2021.693342

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Copyright © 2021 Hu, Li, Wang, Chen, Qian and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toll-like receptor 4 (TLR4)/MyD88 pathway mediates the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in mouse cortex after subarachnoid hemorrhage (SAH). (A–D) After the treatment with GI254023X or MyD88 inhibitory peptide (MIP) fusion protein, the relative mRNA and soluble levels of TREM2 were detected in order to evaluate the regulatory effect of TLR4 on TREM2. (E–I) The protein levels of MyD88, P38, ADAM10, TREM2, and β-actin were quantified by Western blotting. (J) ELISA detection showed the changes of soluble TREM2. These data are shown as mean ± SEM (^ns p>0.05, *p<0.05, **p<0.01, ***p<0.001, ****p<0.001).