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. Author manuscript; available in PMC: 2021 Aug 25.
Published in final edited form as: Pharmacol Biochem Behav. 2020 Jun 20;196:172973. doi: 10.1016/j.pbb.2020.172973

Figure 3. (2R,6R)-HNK treatment (20 mg/kg, i.p.) of the helpless phenotype in adolescent-stress exposed mice.

Figure 3.

(A) The percentage of trials (out of 30) mice failed to escape shock when escape options were available was significantly lower in (2R,6R)-HNK compared to vehicle pretreated mice. Error bars represent S.E.M. Orange and blue dots represent individual female and male mice, respectively. (B) 80.0% of the vehicle-treated mice (8/10, male and female combined) met helpless criteria compared to only 22.2% of the vehicle-treated mice (2/9; male and female combined).