Table 2.
Top 20 pathways associated with DKD
| ID | Pathway description | Gene Ratio | P value | Q value |
|---|---|---|---|---|
| hsa04010 | MAPK signaling pathway | 78/514 | 4.11E-29 | 5.01E-27 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 43/514 | 1.00E-25 | 3.07E-24 |
| hsa04151 | PI3K-Akt signaling pathway | 81/514 | 1.78E-25 | 3.78E-24 |
| hsa04668 | TNF signaling pathway | 40/514 | 2.03E-20 | 2.26E-19 |
| hsa04657 | IL-17 signaling pathway | 35/514 | 1.11E-18 | 9.45E-18 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 32/514 | 1.81E-18 | 1.38E-17 |
| hsa04659 | Th17 cell differentiation | 36/514 | 1.65E-17 | 1.06E-16 |
| hsa04066 | HIF-1 signaling pathway | 36/514 | 3.29E-17 | 2.01E-16 |
| hsa04210 | Apoptosis | 40/514 | 5.52E-17 | 3.06E-16 |
| hsa01522 | Endocrine resistance | 33/514 | 3.70E-16 | 1.88E-15 |
| hsa04014 | Ras signaling pathway | 50/514 | 8.04E-15 | 3.50E-14 |
| hsa04625 | C-type lectin receptor signaling pathway | 31/514 | 1.33E-13 | 4.79E-13 |
| hsa04660 | T cell receptor signaling pathway | 31/514 | 1.33E-13 | 4.79E-13 |
| hsa04810 | Regulation of actin cytoskeleton | 45/514 | 4.88E-13 | 1.53E-12 |
| hsa04015 | Rap1 signaling pathway | 44/514 | 1.03E-12 | 3.13E-12 |
| hsa04919 | Thyroid hormone signaling pathway | 32/514 | 2.04E-12 | 5.93E-12 |
| hsa04620 | Toll-like receptor signaling pathway | 29/514 | 5.39E-12 | 1.46E-11 |
| hsa04218 | Cellular senescence | 36/514 | 6.71E-12 | 1.74E-11 |
| hsa04062 | Chemokine signaling pathway | 40/514 | 8.30E-12 | 2.07E-11 |
| hsa04020 | Calcium signaling pathway | 41/514 | 1.57149E-11 | 3.76249E-11 |