FIG 3.
Pilot screens demonstrate good false-positive rates for the AK assay. (A and B) Screen results from the Cayman FDA library screen (A) and the NCI mechanistic set screen (B). Each data point represents the ZR score of a compound in the library, with red dots indicating ZR < −3.5 (A) or ZR < −6 (B) and green dots indicating ZR > 3.5 (A) or ZR > 3 (B). False-positive (FP) rates are given for each threshold cutoff. (A) The dashed lines delineate −3.5 and 3.5. The dot and dash lines delineate −4.5 and 4.5. (B) Dashed lines delineate −6 and 3.