TABLE 3.
Diagnostic accuracy in measles and rubella antibody detection comparing paired serum and dried blood spot specimensa
| Parameter | % diagnostic accuracy (95% CI) |
|||
|---|---|---|---|---|
| Treating equivocal results as positive results |
Excluding equivocal results |
|||
| Measles | Rubella | Measles | Rubella | |
| Sensitivity | 98.6 (97.2, 99.5) | 98.4 (96.8, 99.3) | 99.4 (98.2, 99.9) | 99.0 (97.6, 99.7) |
| Specificity | 90.0 (73.5, 97.9) | 98.1 (89.7, 100) | 100 (87.2, 100) | 100 (93.0, 100) |
| PPV | 99.4 (98.3, 99.9) | 99.8 (98.9, 100) | 100 (99.3, 100) | 100 (99.2, 100) |
| NPV | 79.4 (62.1, 91.3) | 86.4 (75.0, 94.0) | 90.0 (73.5, 97.9) | 91.1 (80.4, 97.0) |
| % agreement | 98.1 | 98.3 | 99.4 | 99.1 |
| Kappa statistic | 0.83 (0.73, 0.93) | 0.91 (0.85, 0.97) | 0.94 (0.88, 1.00) | 0.95 (0.90, 0.99) |
a
Analysis excludes devices with contamination, extremely low volume, or mislabeling. 95% CI, 95% exact confidence intervals; PPV, positive predictive value; NPV, negative predictive value.