TABLE 1.

hprt mutant frequencies following infection with E. coli Nissle 1917

Treatmenta	MF (×10−6)b	P valuec
Control	5.99 ± 0.98
Cisplatin 10 μM	25.25 ± 5.83	0.006d
Cisplatin 15 μM	47.62 ± 12.60	0.002d
EcN, MOI of 5	5.66 ± 0.71	0.685
EcN, MOI of 10	11.98 ± 5.99	0.425
EcN, MOI of 20	14.49 ± 8.37	0.023d
EcN clbA mutant, MOI of 20	5.46 ± 0.28	0.450
EcN clbP mutant, MOI of 20	4.94 ± 0.51	0.168

^aTreatments were 1 h cisplatin or infection with EcN or clbA or clbP mutants at the given multiplicity of infection (MOI).

^bMF, mutant frequency. The values are the means and standard errors from three independent infection experiments.

^cStatistical analysis compared to control was performed using a two-tailed t test on the log-transformed data.

^dSignificant difference.