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Schematic protein domain structure of Coa and vWbp of S. aureus Newman. Both Coa and vWbp contain N-terminal signal peptides (S) and prothrombin-binding D1 and D2 domains. The C-terminal sequence of Coa contains a linker (L) followed by fibrinogen-binding repeats (R). The C-terminal sequence of vWbp contains a von Willebrand factor binding region between two domains. In S. aureus Newman, Coa and vWbp share 26.3% amino acid identity.
