Table 3.
Neurocognitive Performance of Grouped by DBS Surgery Decision
| Measures | DBS Surgery Conference Decision | Test Statistics | ||||
|---|---|---|---|---|---|---|
| Eligible (n=21) | Not Eligible (n =11) | |||||
| M (SD) | Mz | M (SD) | Mz | t (d) | p a | |
| Global Cognition | ||||||
| OTBM b | −0.4 (0.6) | -- | −0.8 (0.5) | -- | 2.16 (0.82) | .020 |
| DRS-2 Total Score | 129.3 (12.0) | −0.8 | 127.7 (13.8) | −1.0 | 0.31 (0.12) | .378 |
| Attention | ||||||
| DRS-2 Attention | 35.1 (0.9) | 0.0 | 33.7 (3.2) | −0.1 | 1.63 (0.58) | .058 |
| Digit Span Forward | 9.2 (2.4) | −0.3 | 8.5 (1.0) | −0.6 | 1.04 (0.43) | .153 |
| Digit Span Backward | 5.9 (1.9) | −1.0 | 4.0 (1.8) | −1.6 | 2.65 (1.00) | .007 |
| Expressive Language | ||||||
| Phonemic Fluency | 30.9 (12.2) | −0.9 | 20.4 (11.2) | −1.7 | 2.37 (0.90) | .013 |
| Semantic Fluency | 17.9 (7.4) | −0.4 | 13.8 (5.5) | −1.0 | 1.61 (0.63) | .059 |
| Visuospatial | ||||||
| DRS-2 Construction | 5.6 (1.3) | 0.0 | 4.9 (1.9) | −0.4 | 1.19 (0.46) | .123 |
| Verbal Reasoning | ||||||
| DRS-2 Conceptualization | 34.1 (3.1) | −0.6 | 33.0 (4.3) | −0.4 | 0.77 (0.30) | .225 |
| Memory | ||||||
| DRS-2 Memory | 21.6 (3.0) | −0.8 | 21.8 (1.9) | −0.8 | −0.17 (0.07) | .435 |
| CVLT-II Trials 1-5 | 44.0 (11.8) | −0.1 | 37.9 (14.9) | −0.8 | 1.24 (0.45) | .112 |
| CVLT-II Trial B | 4.4 (2.3) | −0.7 | 3.0 (2.1) | −1.4 | 1.65 (0.63) | .055 |
| CVLT-II SDFR | 9.4 (3.8) | 0.1 | 6.2 (4.3) | −1.2 | 2.15 (0.79) | .020 |
| CVLT-II LDFR | 9.6 (4.0) | −0.3 | 6.7 (4.9) | −1.1 | 1.78 (0.64) | .043 |
| CVLT-II Total Discriminability | 2.8 (0.8) | −0.1 | 2.7 (0.8) | −0.3 | 0.19 (0.07) | .427 |
| 10/36 Spatial IR | 18.0 (5.1) | −0.2 | 18.0 (4.3) | 0.0 | 0.00 (0.00) | .500 |
| 10/36 Spatial DR | 6.1 (2.4) | 0.0 | 6.4 (1.9) | 0.3 | −0.34 (0.14) | .368 |
| Executive Functioning | ||||||
| DRS-2 Initiation/Perseveration | 32.9 (6.4) | −0.3 | 33.7 (5.9) | −0.3 | 0.33 (0.13) | .372 |
| WCST 64 Categories c | 2.7 (1.9) | 79% | 1.8 (1.2) | 82% | 1.39 (0.55) | .088 |
| WCST 64 Total Errors | 20.8 (10.7) | −0.4 | 31.6 (8.5) | −1.4 | −2.85 (1.11) | .004 |
| WCST 64 Perseverative Resp. | 15.0 (13.8) | −0.3 | 28.5 (16.2) | −1.5 | −2.41 (0.89) | .012 |
Note. DBS=Deep brain stimulation; Mz is the mean of norm-calibrated z-scores. t=Independent t-test test statistic with corresponding significance (p) and effect size (d). DRS-2=Dementia Rating Scale, 2nd ed; CVLT-II=California Verbal Learning Test, 2nd ed.; SDFR=short delay free recall; LDFR=long delay free recall; 10/36 Spatial IR and DR=10/36 Spatial Recall Test, Immediate Recall and Delayed Recall, respectively; WCST=Wisconsin Card Sorting Test, 64 card version.
p values are 1-tailed to reflect directional hypotheses for cognitive variable analyses.
OTBM scores are based on the mean of norm calibrated z-scores across all cognitive data, barring WCST 64 Categories.
In place of norm-calibrated scores, % within normal limits (based on normative data) shown for WCST 64 Categories.