Table 2. Univariate and multivariate analysis of OTUD3 in overall survival of 115 HCC patients (Cox proportional hazards regression model).
| Parameters | Univariate analysis | Multivariate analysis | ||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Age (≥60/<60) | 0.833 | 0.631-1.305 | 0.531 | — | — | — |
| Gender (Male/Female) | 1.875 | 1.079-2.759 | 0.177 | — | — | |
| Tumor nodule number (Single/Multiple) | 1.164 | 0.631-2.153 | 0.467 | — | — | — |
| AFP(ng/ml) (<400/≧400) | 0.653 | 0.322-1.316 | 0.275 | — | — | — |
| Cirrhosis (Absence/Presence) | 0.756 | 0.431-1.623 | 0.335 | — | — | — |
| Liver function (Child-Pugh A/Child-Pugh B) | 1.632 | 0.731-3.115 | 0.312 | — | — | — |
| Lobe (Right/Left) | 0.693 | 0.413-1.531 | 0.364 | — | — | — |
| Tumor size (≥5/<5) | 1.862 | 0.952-2.879 | <0.01** | 1.503 | 0.911-2.651 | 0.035* |
| TNM (III, IV/I, II) | 2.431 | 1.469-4.021 | <0.01** | 2.213 | 1.336-4.536 | 0.012* |
| Vascular invasion (Positive/Negative) | 2.512 | 1.381-3.513 | <0.01** | 1.756 | 1.351-3.125 | 0.031* |
| Intrahepatic metastasis (Positive/Negative) | 2.058 | 1.617-3.031 | <0.01** | 1.739 | 1.412-2.814 | 0.026* |
| OTUD3 expression (High/Low) | 2.213 | 1.271-3.731 | <0.01** | 1.82 | 1.572-2.681 | 0.016* |
Abbreviation: HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; TNM, tumor–node–metastasis. *P<0.05.