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. 2021 Aug 2;13(15):19486–19509. doi: 10.18632/aging.203360

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Copyright: © 2021 Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Hypoxia-related sketch, immune-related sketch, and tumor infiltrating immune cells in the HIRS based groups in the METABRIC cohort. (A) Correlation between the gene signature and HIF1A. (B) Correlation between HIRS and hypoxia-related genes. (C) GSEA confirmed the hypoxia status in the HIRS-based groups. (D) GSEA of immune-related signaling in the HIRS-based groups. (E–F) ESTIMATE analyses between different risk groups. (G) MCP-counter analyses between different risk groups. (H) CIBERSORT analyses between different risk groups. (I) the expression of immune checkpoint targets between different risk groups.