Figure 2.

Concentration-dependent contractions to PGF_2α (A, B) and phenylephrine (C, D) in isolated aortic rings derived from young and aged eAPP^−/− mice and their respective wild-type (WT) littermates. Results are shown as mean ± SEM (n=9 per group for young WT littermates and eAPP^−/− mice and n=8 per group for aged WT littermates and eAPP^−/− mice) and contractions are expressed as percentage of response to a second KCl (80 mmol/L). No significant differences were detected between WT littermates and eAPP^−/− mice at same age (ANOVA with Bonferroni's correction).