Figure 4.

Effects of aging on ex-vivo secretion of prostaglandins from wild-type (WT) littermates and eAPP^−/− mice aortas. The supernatants were collected and analyzed for TXB₂ (A; n=11 per group for young mice and n=9 per group for aged mice), PGE₂ (B; n=11 per group for young mice and n=9 per group for aged mice); PGF_2α (C; n=8 per group for young mice and n=8 per group for aged mice); and 6-keto PGF_1α (D; n=11 per group for young mice and n=7-9 per group for aged mice). All results were normalized against tissue protein levels and are representing box plots with whiskers showing the median, 25^th to 75^th percentiles, and min-max range. * P<0.05 versus young mice of same strain (two-way ANOVA followed by Tukey’s HSD test).