Table 1. Characteristics of young and aged eAPP−/− mice.
| Parameters | Young | Aged | |||
| WT littermates | eAPP−/− | WT littermates | eAPP−/− | ||
| Body weight (g) | 30±1 (10) | 29±1 (10) | 32±1 (12) * | 33±1 (12) * | |
| SBP (mmHg) | 121±2 (9) | 119±2 (9) | 120±2 (9) | 121±2 (11) | |
| MBP (mmHg) | 93±1 (9) | 92±1 (9) | 94±2 (9) | 95±2 (11) | |
| DBP (mmHg) | 79±1 (9) | 78±1 (9) | 81±2 (9) | 82±2 (11) | |
| Glucose (mg/dL) | 147±8 (10) | 156±11 (10) | 133±7 (12) | 155±10 (12) | |
| Cholesterol (mg/dL) | 63±2 (11) | 63±3 (11) | 88±14 (11) * | 72±3 (11) | |
| HDL (mg/dL) | 54± 2 (11) | 52± 3 (11) | 68±13 (11) | 54±4 (11) | |
| Triglycerides (mg/dL) | 85± 5 (11) | 91± 6 (11) | 74±8 (11) | 63±5 (11) * | |
| Norepinephrine (pg/mL) | 1599±222 (16) | 1898±280 (16) | 3601±1019 (9) * | 3371±399 (7) * | |
| sAPPα (pg/mL) | 549±39 (10) | 244±27 (10) † | 734±72 (12) * | 428±55 (12) *† | |
| Aβ1-40 (pg/mL) | 90±8 (10) | 88±10 (10) | 93±11 (8) | 92±20 (8) | |
SBP indicates systolic blood pressure; MBP, mean blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; WT, wild-type. Data are means ± SEM and the numbers of mice are indicated in the parentheses. * P<0.05 vs. young mice of same strain; † P<0.05 vs. age-matched WT littermates (two-way ANOVA followed by Tukey’s HSD test).