Table 3. Results of different comparative genetic models on the association of CTLA-4 SNPs with RA.

Genetic model	Population	Cases	Controls		Association				Heterogeneity
					OR	95%CI	P-value		Model	I2	P-value
Rs308724
A vs. G	Total	16394	17453		0.87	0.83-0.91	<0.00001		REM	39	0.003
	Caucasian	12830	14148		0.89	0.86-0.93	<0.00001		FEM	25	0.17
	Asian	2859	2393		0.77	0.65-0.90	0.001		REM	56	0.10
	Latin	200	200		0.79	0.60-1.06	0.11		¯	¯	¯
	African	505	712		0.83	0.67-1.02	0.08		¯	¯	¯
AA vs. GG	Total	13046	12214		0.80	0.74-0.87	<0.00001		FEM	22	0.20
	Caucasian	11022	11323		0.81	0.75-0.88	<0.00001		FEM	32	0.13
	Asian	1824	691		0.67	0.48-0.94	0.02		FEM	0	0.48
	Latin	200	200		0.72	0.40-1.31	0.29		¯	¯	¯
AG vs. GG	Total	13046	12214		0.85	0.80-0.90	<0.0001		FEM	28	0.14
	Caucasian	11022	11323		0.86	0.81-0.92	<0.0001		FEM	11	0.33
	Asian	1824	691		0.75	0.48-1.18	0.21		REM	78	0.03
	Latin	200	200		0.61	0.39-0.94	0.02		¯	¯	¯
AA+GA vs. GG	Total	13046	12214		0.83	0.77-0.90	<0.0001		REM	46	0.02
	Caucasian	11022	11323		0.85	0.78-0.93	<0.0002		REM	40	0.07
	Asian	1824	691		0.74	0.48-1.12	0.15		REM	77	0.04
	Latin	200	200		0.60	0.40-0.90	0.01		¯	¯	¯
AA vs. GA+GG	Total	13046	12214		0.88	0.83-0.94	0.0003		FEM	0	0.75
	Caucasian	11022	11323		0.89	0.83-0.95	0.0008		FEM	0	0.60
	Asian	1824	691		0.76	0.55-1.06	0.10		FEM	0	0.98
	Latin	200	200		0.96	0.56-1.65	0.89		¯	¯	¯
Rs231775
G vs. A	Total	11452	12444		1.16	1.08-1.25	<0.0001		REM	66	0.00001
	Caucasian	5884	7872		1.09	1.01-1.19	0.04		REM	38	0.004
	Asian	4804	3511		1.27	1.10-1.47	0.001		REM	71	<0.0001
	African	565	862		1.06	0.68-1.65	0.81		REM	73	0.05
	Latin	199	199		1.45	1.09-1.92	0.010		¯	¯	¯
GG vs. AA	Total	10663	11370		1.29	1.12-1.50	0.0006		REM	54	0.0002
	Caucasian	5600	7510		1.11	0.94-1.31	0.21		FEM	25	0.17
	Asian	4804	3511		1.58	1.24-2.01	0.0002		REM	51	0.01
	African	60	150		0.68	0.28-1.65	0.39		¯	¯	¯
	Latin	199	199		1.24	1.09-1.42	0.03		¯	¯	¯
GA vs. AA	Total	10663	11370		1.19	1.07-1.32	0.001		REM	46	0.003
	Caucasian	5600	7510		1.18	1.02-1.35	0.02		REM	59	0.001
	Asian	4804	3511		1.20	1.05-1.38	0.08		FEM	3	0.42
	African	60	150		0.87	0.36-2.11	0.76		¯	¯	¯
	Latin	199	199		1.88	1.20-2.94	0.006		¯	¯	¯
GG+GA vs. AA	Total	10663	11370		1.24	1.11-1.39	0.0001		FEM	56	0.001
	Caucasian	5600	7510		1.17	1.02-1.34	0.02		REM	62	0.0006
	Asian	4804	3511		1.33	1.17-1.51	<0.0001		FEM	31	0.12
	African	60	150		0.77	0.34-1.76	0.53		¯	¯	¯
	Latin	199	199		1.87	1.23-2.85	0.003		¯	¯	¯
GG vs. GA+AA	Total	10663	11370		1.15	1.02-1.30	0.02		REM	57	<0.0001
	Caucasian	5600	7510		1.01	0.91-1.12	0.80		FEM	10	0.34
	Asian	4804	3511		1.34	1.08-1.65	0.008		REM	72	<0.0001
	African	60	150		0.75	0.41-1.38	0.36		¯	¯	¯
	Latin	199	199		1.30	0.79-2.15	0.31		¯	¯	¯
Rs5742909
T vs. C	Total	2477	2941		1.21	0.93-1.57	0.15		REM	71	0.0003
	Caucasian	1813	2167		1.31	0.94-1.84	0.11		REM	73	0.005
	Asian	464	574		1.05	0.56-1.96	0.88		REM	80	0.002
	Latin	200	200		1.00	0.53-1.89	1.00		¯	¯	¯
TT vs. CC	Total	2193	2579		1.71	1.08-2.73	0.08		FEM	17	0.30
	Caucasian	1529	1805		1.58	0.60-4.17	0.35		REM	32	0.22
	Asian	464	574		1.34	0.34-5.28	0.68		REM	56	0.13
	Latin	200	200		4.95	0.24-103.73	0.30		¯	¯	¯
TC vs. CC	Total	2193	2579		1.19	0.84-1.69	0.33		FEM	76	<0.0001
	Caucasian	1529	1805		1.27	0.81-1.99	0.29		REM	74	0.01
	Asian	464	574		1.16	0.53-2.56	0.70		REM	83	0.0004
	Latin	200	200		0.79	0.40-1.58	0.51		¯	¯	¯
TT+TC vs. CC	Total	2193	2579		1.19	0.84-1.69	0.33		FEM	77	<0.0001
	Caucasian	1529	1805		1.28	0.79-2.07	0.32		REM	78	0.003
	Asian	464	574		1.12	0.52-2.43	0.77		REM	84	0.0003
	Latin	200	200		0.89	0.46-1.74	0.73		¯	¯	¯
TT vs. TC+CC	Total	2193	2579		1.43	0.90-2.27	0.13		FEM	0	0.52
	Caucasian	1529	1805		1.46	0.77-2.78	0.25		FEM	0	0.39
	Asian	464	574		1.27	0.63-2.54	0.51		FEM	32	0.23
	Latin	200	200		5.05	0.24-105.86	0.30		¯	¯	¯

OR, odds ratio; CI, confidence interval; FEM, fix-effect model; REM, random-effect model.