FIGURE 1.

Rare, deleterious coding variants identified in sEOAD or PCA patients. A, Schematic presentation of the number of variants among selected genes resulting at each step of screening. B, Flow diagram of dementia-associated gene selection and classification using different online databases. C, Presentation of rare, deleterious protein-altering variants of selected genes in recruited sEOAD or PCA patients with different gray scales representing different pathogenicity according to American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP). AD indicates Alzheimer disease; LP, likely pathogenic; PAT, pathogenic; PCA, posterior cortical atrophy; sEOAD, sporadic early-onset Alzheimer disease; VUS, variant of uncertain significance.