Table 5.
Statistics for RNAi knockdown of Gid orthologs in C. elegans.
| Exp | Strain/plasmid for RNAi | Effect on Life Span | P (vs. Ctrl) | Mean Life Span (days ± 2SEM) | Mean Life Span (%) | 1Max Life Span (days ± 2SEM) | Max Life Span (%) | No of uncensored worms |
|---|---|---|---|---|---|---|---|---|
| #1 Figure 6A,B |
N2/ L4440 |
16.4 ± 0.3 | 100 | 18.4 ± 0.4 | 100 | 210 | ||
| N2/ f53e2.1 |
↑ | **** | 19.9 ± 0.3 | 121.4 | 22.8 ± 0.5 | 123.9 | 359 | |
| N2/ t07d1.2 |
↑ | **** | 21.6 ± 0.3 | 131.4 | 24.8 ± 0.5 | 134.8 | 358 | |
| N2/y39h10a.6 | ↑ | **** | 20.5 ± 0.3 | 124.6 | 23.2 ± 0.5 | 126.1 | 347 | |
| N2/y54e5a.7 | ↑ | **** | 21.3 ± 0.3 | 129.5 | 23.6 ± 0.4 | 128.3 | 351 | |
| #2 | N2/ L4440 |
15.5 ± 0.2 | 100 | 17.2 ± 0.8 | 100 | 137 | ||
| N2/ f53e2.1 |
↑ | **** | 20.7 ± 0.3 | 133.3 | 23.6 ± 0.4 | 137.2 | 252 | |
| N2/ t07d1.2 |
↑ | **** | 22.6 ± 0.2 | 153.5 | 26.4 ± 0.7 | 145.6 | 267 | |
| N2/y39h10a.6 | ↑ | **** | 22.1 ± 0.2 | 142.8 | 25.5 ± 0.4 | 148.3 | 256 | |
| N2/y54e5a.7 | ↑ | **** | 23.0 ± 0.3 | 148.1 | 27.4 ± 0.4 | 159.3 | 266 |
a75% quantile
bSEM standard error of the mean of 5 technical replicates
cControl: N2/L4440; **** P < 0.0001