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. 2019 Dec 29;16(10):1807–1822. doi: 10.1080/15548627.2019.1704117

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Cardiomyocyte-specific knockdown of INHB/activin receptor babo delays cardiac aging. (A-C) Age-dependent changes in cardiac arrhythmia, diastolic intervals, and heart period in control (Ctrl) and cardiomyocyte-specific babo knockdown flies (babo ^RNAi). Flies were cultured at 40% relative humidity. tinc-gal4 driver was used. Results from two independent UAS-babo^RNAi lines are shown (RNAi #1: BDSC, 25933, RNAi #2: BDSC, 40866). N = 15 ~ 30. One-way ANOVA (*** p < 0.001, ** p < 0.01, * p < 0.05, ns = not significant). (D-F) Changes in cardiac arrhythmia, diastolic intervals, and heart period in fly hearts expressing constitutively activated babo (babo^Act). GeneSwitch heart driver Hand-GS-gal4 was used to induce adult-onset babo activation. RU: RU486 (Mifepristone). Flies were cultured at 40% relative humidity. N = 6 ~ 9. One-way ANOVA (*** p < 0.001, ** p < 0.01, * p < 0.05, ns = not significant).